Aims of Study
This therapy was performed to determine the effects of intravesical oxybutynin hydrochloride in patients of neurogenic bladder storage dysfunction.

Methods
The sujects were nine patients of neurogenic bladder storage dysfunction that have a overactive and/or low compliance detrusor dysfunction. Their baseline diseases were four patients of chronic spinal cord injury, two of spina bifida and a transverse myelopathy, a multiple sclerosis, a unknown disease. We treated by dissolved water with four to six mg (mean five mg) oxybutynin hydrochloride. We examined a subjective symptom and objective parameters by urodynamic studies. There are a maximum bladder capacity, a maximum bladder static pressure, a maximum bladder pressure and bladder compliance.

Results
We had seven cases of good effects in intravesical oxybutynin instillation therapy. But, one case had been a little effects and other one case had been no effects. In urodynamic parameters, bladder capacity after instillation increased than before one. But, it was not significant. Bladder compliance after instillation significantly improved.

Conclusions
It was suggested that intravesical oxybutynin instillation therapy effects in detrusor relaxation and enlarged bladder capacity. I think that this effect is direct bladder infiltration of oxybutynin hydrochloride.

Reference
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2) Massad CA et al: The pharmacokinetics of intravesical and oral oxybutynin hydrochloride. J Urol. 148:595-598, 1992.
3) Mizunaga M et al: Intravesical instillation of oxybutynin hydrochloride therapy for patients with neuropathic bladder.
4) Kasabian NG et al: The use of intravesical oxybutynin hydrochloride in patients with detrusor hyperreflexia. J Urol. 151: 944-945, 1994.
5) Yokoyama O et al: Urodynamic effects of intravesical oxybutynin hydrochloride in concious rats. J Urol. 155: 768-771, 1996.